The show's most prolific directors through its first six seasons were Deran Sarafian (22 episodes), who was not involved in season six, and Greg Yaitanes (17).Of the more than three dozen other directors who have worked on the series, only David Straiton directed as many as 10 episodes through the sixth season.Shore recalled: "I knew, as soon as I left the room, they would be mocking me relentlessly [for my cluelessness] and I thought that it would be interesting to see a character who actually did that before they left the room." The original idea was for House to use a wheelchair, but Fox rejected this.
Australian actor Jesse Spencer's agent suggested that he audition for the role of Dr. Spencer believed the program would be similar in style to General Hospital, but changed his mind after reading the scripts.
Through the end of the sixth season, more than two dozen writers have contributed to the program.
The most prolific have been Kaplow (18 episodes), Blake (17), Shore (16), Friend (16), Lerner (16), Moran (14), and Egan (13).
Robert Sean Leonard, who portrays Wilson, said that House and his character—whose name is very similar to Watson's—were originally intended to work together much as Holmes and Watson do; in his view, House's diagnostic team has assumed that aspect of the Watson role.
Individual episodes of the series contain additional references to the Sherlock Holmes tales.